Six cases of immature teratoma of the ovary with neural component are analyzed and grouped into 3 grades according to the amount of neural epithelium. Immunohistochemical reaction of GFAP, vimentin, NSE and S-100 protein on a varicty of neural tissue as a tumor component is studied.
The neural epithelium within the immature teratoma is arranged in tubules, rosettes and diffuse sheets, which are often associated with astrocytes and glial fibers on their background.
Vimentin is found in a marked increase, whereas NSE reveals a mild increase in the neuroblasts. No detectable amount of GFAP and S-100 proteins present in the neural epithelium.
Astrocytes, ependymal cells, and glial fibers are all reactive to GFAP, vimentin, NSE, and S-100 protein. The positive reaction is helpful to find neural epithelium with no difficulty.
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